职 称：副高

学 历：博士

E-mail:sevenzhu7@126.com

研究方向：微生物代谢调控

工作经历：

2009/07-今 湖北工业大学 生物工程与食品学院 高级实验师

2012/09-2017/06 武汉大学 健康学院 博士

2006/09-2009/06 湖北工业大学 生物工程学院 硕士 2003/09-2006/06 湖北工业大学 生物工程学院 学士

荣获奖励：

2016年湖北省自然科学奖一等奖“天然产物生物制造的理论与方法”，排名第3；

2014年湖北省科技进步奖一等奖“工业微生物发酵关键技术及产业化”，排名第8；

2011年湖北省自然科学奖二等奖“食用菌液体发酵”，排名第5。

研究课题：

1.发酵工程教育部重点实验室开放基金“基于转录因子Cra全局调控促进琥珀酸生物合成的机制研究”，2021/05-2023/04。

2.国家自然科学基金青年基金“大肠杆菌全局转录因子Cra对琥珀酸生物合成过程中CO2固定基因的调控机制”，2016/01-2018/12。

研究成果：

1.Lin-Yang Sun1, Li-Wen Zhu1, Ya-Jie Tang*. Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4'-demethylepipodophyllotoxin derivatives. Scientific Reports 2018, 8:14949 (IF=4.011) (1 with equal contribution to this work)

2.Li-Wen Zhu, Ya-Jie Tang*. Current advances of succinate biosynthesis in metabolically engineered Escherichia coli. Biotechnology Advances 2017, 35:1040-1048 (IF=10.744)

3.Li-Na Wei1, Li-Wen Zhu 1, Ya-Jie Tang*. Succinate production positively correlates with the affinity of the global transcription factor Cra for its effector FBP in Escherichia coli. Biotechnology for Biofuels 2016, 9:624 (IF=5.203) (1 with equal contribution to this work)

4.Jun-Han Yu1, Li-Wen Zhu 1, Shi-Tao Xia1, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering 2016, 113:1531-1541. (IF=4.481) (1 with equal contribution to this work)

5.Li-Wen Zhu 1, Shi-Tao Xia1, Li-Na Wei, Hong-Mei Li, Zhan-Peng Yuan*, Ya-Jie Tang*. Enhancing succinic acid biosynthesis in Escherichia coli by engineering its global transcription factor, catabolite repressor/activator (Cra). Scientific Reports 2016, 6:36526. (IF=4.259)

6.Li-Wen Zhu 1, Lei Zhang1, Li-Na Wei, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tan**. Collaborative regulation of CO2 transport and fixation during succinate production in Escherichia coli. Scientific Reports 2015, 5:17321. (IF=5.228) (1 with equal contribution to this work)

7.Li-Wen Zhu, Xiao-Hong Li, Hong-Mei Li, Jian-Hua Liu, Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli. Metabolic Engineering. 2013, 20:9-19 (IF=8.258)

8.Li-Wen Zhu, Cheng-Cheng Wang, Rui-Sang Liu, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Actinobacillus succinogenes ATCC 55618 fermentation medium optimization for the production of succinic acid by response surface methodology. Journal of Biomedicine and Biotechnology Volume 2012, Article ID 626137, 9 pages doi:10.1155/2012/626137, 2012. (IF=2.706)

9.Cheng-Cheng Wang, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Performance analyses of a neutralizing agent combination strategy for the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Bioprocess and Biosystems Engineering 35: 659-664, 2012. (IF=1.823)

10.Wei Zou, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Significance of CO2 donor on the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Microbial Cell Factories. 10: 87, 2011. (IF=4.250)

11.Li-Wen Zhu, Jian-Jiang, Zhong, Ya-Jie Tang*. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidum. Process Biochemistry 2010, 45: 1904-1911. (IF=2.524)

12.Li-Wen Zhu, Ya-Jie Tang*. Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides by Ganoderma lucidum. Bioprocess and Biosystems Engineering 2010, 33: 999-1005. (IF=1.823)

13.Ya-Jie Tang*, Li-Wen Zhu. Improvement of ganoderic acid and Ganoderma polysaccharide biosynthesis by Ganoderma lucidum fermentation under the inducement of Cu2+. Biotechnology Progress 26: 417-423, 2010. (IF=1.883)

14.Ya-Jie Tang*, Wei Zhang, Rui-Sang Liu, Li-Wen Zhu, Jian-Jiang Zhong. Scale-up study on the fed-batch fermentation of the medicinal mushroom Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides in stirred-tank bioreactor. Process Biochemistry 46: 404-408, 2011. (IF=2.524)

15.Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Significance of fungal elicitors on the production of Ganoderma polysaccharides and ganoderic acid by submerged fermentation of medicinal mushroom Ganoderma lucidum. Process Biochemistry 2008, 43:1359-1370. (IF=2.524)

16.Ya-Jie Tang*, Li-Wen Zhu, Hong-Mei Li, Dong-Sheng Li. Submerged culture of mushroom in bioreactors - challenges, current state-of-the-art, and future prospects. Food Technology and Biotechnology 2007, 45(3):221-229. (IF=0.977) (Invited Review)

朱丽雯，孙林阳，汤亚杰*. 琥珀酸生物合成过程中CO2代谢调控的研究进展。中国科学 2017, 47(5):563-571。

中国发明专利：促进灵芝次生代谢产物合成的细胞培养方法，ZL200810001055.9 (排名第3)