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大健康与精准医药营养团队—王军团队

作者: 时间:2020-05-23 浏览次数:

一、团队名称

大健康与精准医药营养团队

二、团队组成

负责人:王军(博士、教授)

其他团队成员全职副教授1名,讲师2名;海内外兼职教授3名(院士2名、国务院特殊津贴专家1名),海外兼职副教授3

三、团队介绍

团队研究方向: 自由基在急慢性疾病中的检测、功能与机制的基础与转化研究

主要研究内容:(1)孤独症谱系障碍中氧化应激生物标志物的鉴定与灵敏检测;(2)自由基在神经发育中的作用与机制;(3)自由基与炎症因子风暴的清除与药物设计。团队固定教师10名,其中教授4人、副教授4人、讲师2。研究工作覆盖神经生物学、免疫学、生物化学、分子生物学与分析化学等学科交叉领域,在国际自由基生物医学领域具有行业影响力。

团队依托科研平台:国家外专局/教育部“细胞调控与分子药物111引智基地” (科学研究)、发酵工程教育部重点实验室(科学研究)、大健康与精准医药营养中心(成果转化)。团队承担了科研项目10项,省级基金项目4项,近三年研究项目近280万元,发表SCI文章30余篇,授权发明专利5项,获国内国际奖10余项。

四、科研成果

1)代表性的科研项目:

湖北省高端人才启动基金项目人体一氧化氮合成酶机理和功能的基础研究

111引智基地国际合作项目一氧化氮在巨噬细胞中的作用与机制

校企合作重大项目孤独症儿童营养支持食品研发及产业化应用

校企合作重大项目特殊医学用途食品中一氧化氮的检测

2)代表性果获奖:

2013年国际硝酸盐亚硝酸盐生理及医学大会摘要奖;

2018年第一届全国维康杯酸奶竞赛二等奖;

2018年国家级大学生创新创业项目获批;

2019年省级大学生创新创业项目获批;

2019年省级教研虚拟仿真项目获批。

3)代表性论文:

1. Fu H.; Deng W.; Yao L.; Gong M.; Lai S.; Liu J.; Li M.;, Xu H.; Wang J. * “Urinary NOx, a novel potential biomarker for autism spectrum disorder” Free Radical Biology & Medicine 2020, 146, 350.  doi: 10.1016/j.freeradbiomed.2019.11.001.  IF: 5.66.

2. Wang L.; Sparacino-Watkins CE.; Wang J.; Wajih N.; Varano P.; Xu Q.; Cecco E.; Tejero J.; Soleimani M.; Kim-Shapiro DB.; Gladwin MT. “Carbonic Anhydrase II Does Not Regulate Nitrite Dependent Nitric Oxide Formation and Vasodilation”  British Journal of Pharmacology 2020, 177, 898. doi: 10.1111/bph.14887. IF: 6.81.

3. Liu L.; Ding C.; Tian M.; Yi D.; Wang J.; Zhao J.; Hu Y.; Wang C. “Fermentation improves the potentiality of capsicum in decreasing high-fat diet-induced obesity in C57BL/6 mice by modulating lipid metabolism and hormone response” Food Research International 2019, 24, 49-60. IF: 3.58.

4. Hu, C.; Zhang, H.; Zhang, M.; Mi, Z.; Wang, J.; Lu, W.; Su, J. “Identication, Characterization and High-Performance Liquid Chromatography Quantication for Process-Related Impurities in Abiraterone Acetate Bulk Drug” Journal of Chromatographic Science 2018, 1. IF: 1.22.

5. Wang, J. *; Keceli, G.; Cao, R.; Su. J.; Mi, Z. “Molybdenum-containing nitrite reductases: Spectroscopic characterization and redox mechanism” Redox Report 2017, 1, 17. IF: 1.96

6. Wang, J.; Krizowski, S.; Fischer, K; Niks, D.; Tejero, J.; Wang, L.; Sparacino-Watkins, C; Ragireddy, V.; Frizzell, S.; Kelley, E.E.; Zhang, Y.; Basu, P.; Hille, R.; Schwarz, G.; Gladwin, M.T. “Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide” Antioxidants & Redox Signaling 2015, 23, 283. IF: 5.83

7. Zhao, J.; Wang, J.; Yang, Y.; Lu, Y. “The Determination of Nitrate and Nitrite in Human Urine and Blood by High-Performance Liquid Chromatography and Cloud-Point Extraction” Journal of Chromatographic Science. 2015, 53, 1169. IF: 1.22

8. Zhao, J.; Lu, Y.; Fan, C.; Wang, J.; Yang, Y. “Development of a cloud point extraction and spectrophotometry-based microplate method for the determination of nitrite in human urine and blood” SAA 2015, 136, 802. IF: 2.93.

9. Liu C.; Wajih N.; Liu X.; Basu S.; Janes J.; Marvel M.; Keggi C.; Helms C.C.; Lee A.N.; Belanger A.M.; Diz D.I.; Laurienti P.; Caudell D.L.; Wang J.; Gladwin M.T.; Kim-Shapiro D.B. “Mechanisms of Human Erythrocytic Bioactivation of Nitrite” Journal of Biological Chemistry 2015, 290, 1281. IF: 4.11.

10. Sparacino-Watkins, C.; Tejero, J.; Sun, B.; Gauthier, M.C.; Thomas, J.; Ragireddy, V.; Merchant, B.A.; Wang, J.; Azarova, I.; Basu, P.; Gladwin, M.T.  “Nitrite Reductase and NO Synthase Activity of the Mitochondrial Molybdopterin Enzyme mARC 1 and mARC 2” Journal of Biological Chemistry 2014, 289, 10345. IF: 4.11.

11. Zhao, X-J; Shiva, S.; Tejero, J.; Wang, J.; Frizzell, S.; Gladwin, M.T. “Mechanisms for Cellular NO Oxidation and Nitrite Formation in Lung Epithelial Cells” Free Radical Biology & Medicine 2013, 61,428. IF: 5.66.

12. Bueno, M.; Wang, J.; Mora A.L.; Gladwin, M.T. “Nitrite Signaling in Pulmonary Hypertension: Mechanisms of Bioactivation, Signaling and Therapeutics” Antioxidant & Redox Signaling 2013, 18, 1797. IF: 5.83.

13. Wang, J.; Schopfer, M. P.; Puiu, S. C.; Sarjeant, A. A. N.; Karlin, K. D. “Reductive Coupling of Nitrogen Monoxide (•NO) Facilitated by Heme/Copper Complexes” Inorganic Chemistry 2010, 49, 1404. IF: 4.85.

14. Schopfer, M. P.; Wang, J.; Karlin, K. D. “Bioinspired Heme, Heme/Nonheme Diiron, Heme/Copper, and Inorganic NOx Chemistry: •NO(g) Oxidation, Peroxynitrite-Metal Chemistry, and •NO(g) Reductive Coupling”  Inorganic Chemistry 2010, 49, 6267. IF: 4.85.

15. Wang, J.; Schopfer, M. P.; Sarjeant, A. A. N.; Karlin, K. D. “Heme-Copper Assembly Mediated Reductive Coupling of Nitrogen Monoxide (•NO)” The Journal of American Chemical Society 2009, 131, 450. IF: 14.70.

16. Wen-Wen Deng; Yu Zong; Yu-Xiu Xiao*; Hexafluoroisopropanol-Based Deep Eutectic Solvent/Salt Aqueous Two-Phase Systems for Extraction of Anthraquinones from Rhei Radix et Rhizoma Samples, ACS Sustainable Chemistry & Engineering, 2017, 5: 4267-4275.

17. Wenwen Deng#; Long yu#; Xiao Li; Jia Chen; Xuanxuan Wang; Zixin Deng; Yuxiu Xiao*; Hexafluoroisopropanol-based hydrophobic deep eutectic solvents for dispersive liquid-liquid microextraction of pyrethroids in tea beverages and fruit juices, Food Chemistry, 2018, 274: 891-899.

18. Anqi Huang#; Wenwen Deng#; Dandan Wu; Shuwen Wu*; Yuxiu Xiao*; Hexafluoroisopropanol-salt aqueous two-phase system for extraction and purification of chlorogenic acid from ramie leaves, Journal of Chromatography A, 2019, 1597:196-201.  

19. Ying Deng, Yonglong Pan, Meizhong Luo Detection and correction ofassembly errors ofrice Nipponbare reference sequence.Plant Biology 2014. 16: 643 - 650

4)代表性专利:

肖玉秀,邓文文; 一种小分子氟醇-盐双水相体系及其萃取方法,专利号:CN201710996118.8.

杨亚玲,赵娇,宁金艳,王军,吕云辉;一种血液中亚硝酸盐的检测方法,专利号:CN103760121 B

五、研究生毕业去向

1、硕士研究生:

推荐到省级事业单位、上市公司等院所、大型企业工作;推荐到国内外著名高校读博

六、联系方式

联系人:

邮箱:jun_wang@hbut.edu.cn2491549178@qq.com


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