职称：讲师
学历：博士
E-mail：xugang@@hbut.edu.cn
研究方向：病毒感染与宿主免疫应答
学习工作经历：
2024.7-至今湖北工业大学生命科学与健康工程学院讲师
2021.12-2024.4武汉迈瑞生物医疗科技有限公司试剂开发资深工程师
2019.11-2021.11武汉大学生命科学学院博士后
2013.9-2019.12武汉大学生命科学学院微生物学博士
2009.9-2013.6武汉大学生命科学学院生命科学与技术基地班学士
研究课题：
1. “十四五”国家重点研发计划项目子课题、2021YFC2701804、重症感染儿童的病原致病机制和分子标志物研究、2021-2024、500万元、在研、参与。
2. 国家自然科学基金委员会青年科学基金项目、31500149、MVP在甲型流感病毒诱导的细胞因子风暴中的作用及机制研究、2016-2018、23万元、已结题、参与。
研究成果：
1.Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y. Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.Cell Mol Immunol.2021 Jun;18(6):1587-1589.（IF: 24.1）
2.Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S. Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.PLoS Pathog.2019Aug 12;15(8):e1008002.（IF: 6.7）
3.徐刚,刘实, &朱应. Ⅲ型干扰素最新研究进展.中国科学:生命科学. 2015;45(2):142-155.
4.Deng F,Xu G, Cheng Z, Huang Y, Ma C, Luo C, Yu C, Wang J, Xu X, Liu S, Zhu Y. Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.Front Immunol.2021 Feb 25;12:618196.（IF: 7.3）
5.Xia Z,Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y. NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.J Immunol.2019Aug 15;203(4):1001-1011.（IF: 4.4）
6.Xia Z,Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y. Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.J Immunol.2017May 1;198(9):3690-3704.（IF: 4.4）
7.Zhao F,Xu G,Zhou Y, Wang L, Xie J, Ren S, Liu S, Zhu Y. MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein.J Biol Chem.2014Dec 12;289(50):35029-41.（IF: 4.8）
8.He QQ, Huang Y, Nie L, Ren S,Xu G, Deng F, Cheng Z, Zuo Q, Zhang L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Lu M, Lu Z, Zhu Y, Liu S. MAVS integrates glucose metabolism and RIG-I-like receptor signaling.Nat Commun.2023 Sep 2;14(1):5343.（IF: 16.6）
9.Liu S, Peng N, Xie J, Hao Q, Zhang M, Zhang Y, Xia Z,Xu G, Zhao F, Wang Q, Han T, Zhu Y. Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways.J Hepatol.2015 May;62(5):1015-23.（IF: 25.7）
10.Cao W, Guo Y, Cheng Z,Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y. Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.J Immunol.2021 Jun 1;206(11):2668-2681.（IF: 4.4）
11.Zuo Q, Cheng Z, Zhang G, Xia Y,Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y. Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.J Immunol.2021 Jul 15;207(2):577-589.（IF: 4.4）
12.Liu S, Liu L,Xu G, Cao Z, Wang Q, Li S, Peng N, Yin J, Yu H, Li M, Xia Z, Zhou L, Lin Y, Wang X, Li Q, Zhu C, Yang X, Wang J, She Y, Lu M, Zhu Y. Epigenetic Modification Is Regulated by the Interaction of Influenza A Virus Nonstructural Protein 1 with the De Novo DNA Methyltransferase DNMT3B and Subsequent Transport to the Cytoplasm for K48-Linked Polyubiquitination.J Virol.2019 Mar 21;93(7):e01587-18.（IF: 5.4）
13.Zhou Y, Xia Z, Cheng Z,Xu G,Yang X, Liu S, Zhu Y. Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.J Biol Chem.2018 Nov 23;293(47):18168-18179.（IF: 4.8）
14.Yang X, Hao H, Xia Z,Xu G, Cao Z, Chen X, Liu S, Zhu Y. Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway.J Immunol.2016 Sep 15;197(6):2369-81.（IF: 4.4）
15.Wang L, Zhu S,Xu G, Feng J, Han T, Zhao F, She YL, Liu S, Ye L, Zhu Y. Gene Expression and Antiviral Activity of Interleukin-35 in Response to Influenza A Virus Infection.J Biol Chem.2016 Aug 5;291(32):16863-76.（IF: 4.8）
16.Cao Z, Zhou Y, Zhu S, Feng J, Chen X, Liu S, Peng N, Yang X,Xu G, Zhu Y. Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome.Sci Rep.2016 Feb 24;6:22002.（IF: 4.6）
17.Gui S, Chen X, Zhang M, Zhao F, Wan Y, Wang L,Xu G, Zhou L, Yue X, Zhu Y, Liu S. Mir-302c mediates influenza A virus-induced IFNβexpression by targeting NF-κB inducing kinase.FEBS Lett.2015 Dec 21;589(24 Pt B):4112-8.（IF: 3.5）
